In 1960, Thomas Francis Jr., MD, a professor of epidemiology at the University of Michigan who was the first to isolate the influenza virus in the U.S., published a paper titled “On the Doctrine of Original Antigenic Sin” in the Proceedings of the American Philosophical Society that is pertinent to our understanding of immunological memory to this day.
Sadly, the concept of original antigenic sin (OAS) has not been given the scrutiny it deserves. …